Biopharmaceutical Relevance of Human
Nasal Primary Cell Culture Systems

By Remigius Uchenna AGU
December 2002
Leuven University Press
ISBN: 90-5867-265-4
163 pages, Illustrated, 6 1/4" x 9 1/2"
$57.50 Paper Original

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Contents of this doctoral dissertation include: Biopharmaceutical basis for in vitro nasal drug delivery assessment, Barriers to nasal drug absorption, Development of collagen matrix-based human nasal primary cell culture systems for in vitro drug delivery studies, Validation of human nasal primary cell culture systems for drug absorption studies, Validation of human nasal primary cell culture systems for drug metabolism studies, Assessment of Absorption enhancement strategies for therapeutic peptides using human nasal primary cell culture systems, Identification and characterization of human nasal L-amino acid transporters using nasal primary cell culture system, Mechanistic appraisal of acute and subacute drug excipients-related ciliotoxicity using a primary cell culture model, General discussion and Summary.

Pharmacology
Acta Biomedica Lovaniensia No. 271

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