Cardioselective Nitric Oxide Synthase Gene
Transfer to Target Myocardial Ischemia

By Zsolt Szelid
March 2005
Leuven University Press
ISBN: 9058674541
100 pages, Illustrated, 6 " x 9 "
$69.50 Paper Original


This is a Ph.D. dissertation. Contents include: Introduction: Cardiovascular and myocardial gene transfer, Gene delivery strategies to the cardiovascular system, Gene vector design, Adenovirus-mediated immunity and cardiovascular gene transfer, Myocardial gene transfer to target myocardial ischemia - reperfusion injury; Specific aims; Materials and methods: Construction of recombinant virus, Myocardial transfer and anti-adenoviral immunity, Gene transfer and myocardial ischemia-reperfusion injury, Statistical analysis; Results: Anti-adenoviral immunity and myocardial adenoviral gene transfer, Gene transfer and myocardial ischemia-reperfusion injury; Discussion: Pre-existing anti-adenoviral immunity and adenovirus-mediated myocardial gene transfer, Intramyocardial NOS3 gene transfer and adenovirus-mediated immune responses, Cardioselective NOS3 gene transfer and myocardial protection from reperfusion injury; General conclusions.



Cardiology
Acta Biomedica Lovaniensia, No. 337

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