Characterization of the Glypican
Receptor Receptor Function


By Bart De Cat
September 2004
Leuven University Press
ISBN: 9058673936
124 pages, Illustrated, 6 " x 9 "
$87.50 Paper Original


This is a Ph.D. dissertation. Contents include: Introduction, Heparan Sulfate Proteoglycans, Glypicans: Proteoglycans with a surprise, Proteoglycan function in cell-cell signaling, Trafficking and turnover of proteoglycans, Rationale, aims and approaches, Material and methods, Results and discussion, Processing by proprotein convertases is required for GPC-3 modulation of cell survival, WNT signaling and gastrulation movements, Defective intracellular transport and processing of the W296R GPC3 mutant, Conclusions, GPC3 function depends on core protein processing, Dysfunction of GPC3 W296R in the Simpson-Golabi-Behmel Syndrome (SGBS), General Discussion & Perspectives, GPC3: A versatile modulator of WNT Signaling, Pro-protein convertase-mediated GPC processing, Interactions between GPCS and WNT pathways, Amino acid variants: clues to Glypican Biology, Summary.

Biochemistry
Acta Biomedica Lovaniensia No. 319

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