Characterization of the Presenilin
1-Telencephalin Interaction &
Implications for Alzheimer's Disease

By Cary Esselens
August 2005
Leuven University Press
ISBN: 9058674681
134 pages, Illustrated, 6 " x 9 "
$87.50 Paper Original

This is a Ph.D. dissertation. Alzheimer's disease is a neurodegenerative late-onset disease. Important players in the pathogenesis of Alzheimer's disease are the amyloid precursor protein (APP) but also the proteases or secretases that cleave this type I transmembrane protein, not in the least because short proteolytic peptide fragments of APP, called Amyloid B peptides, clearly accumulate in the brain of Alzheimer's patients.

Contents include: Scientific publications, Abbreviations, Summary, Introduction and Objectives, Materials and Methods, Interaction studies for APP, PS1 and TLN predict a ring structure for presenilins, Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway, Towards a strategy to selectively lower lower AB production suing peptide-based y-secretase inhibitors.

Acta Biomedica Lovaniensia, No. 344

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