Cancer Risk Assessment at the Workplace
Cancer Risk of Workers Exposed to Styrene & the Influence of
Genetic Polymorphisms of Enzymes Involved in Metabolism & DNA Repair
Acta Biomedica Lovaniensia, No. 358
By Lode Godderis
September 2006
Leuven University Press
Ph.D. Dissertation
ISBN: 9058675351
174 pages, Illustrated, 6 1/8 x 9 3/8"
$99.50 Paper Original
1.Introduction
1.1. Concepts and biomarkers in cancer risk assessment
1.2. Rad-equivalence
1.3. Summary on most important data on styrene, ethylene oxide and gamma-radiation
1.4. Susceptibility
2. Objectives and methods of the thesis
2.1. To assess whether low level exposure to styrene can induce hemoglobin adducts and genotoxic effects
2.2. To assess the in vitro genotoxic potency of styrene 7,8-oxide and ethylene oxide compared to gamma-radiation
2.3. To calculate the cancer risk of workers exposed to 20 ppm styrene by means of the rad-equivalence approach
2.4. To investigate whether genetic polymorphisms in genes coding for enzymes involved in metabolism and/or DNA repair can explain individual differences in genotoxic responses
3. Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers
3.1. Introduction
3.2. Materials and methods
3.3. Results
3.4. Discussion
4. Comparison of in vitro genotoxicity by styrene 7,8-oxide, ethylene oxide and gamma-radiation and human
cancer risk assessment of styrene using the rad-equivalence approach
4.1. Introduction
4.2. Materials and methods
4.3. Results
4.4. Discussion
5. Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene 7,8-oxide, ethylene oxide and gamma-radiation
5.1. Introduction
5.2. Materials and methods
5.3. Results
5.4. Discussion
General discussion
6.1. Does low level exposure to styrene induce hemoglobin adducts and genotoxic effets?
6.2. Comparison of the in vitro genotoxic potency of styrene 7,8-oxide, ethylene oxide and gamma-radiation; and calculation of the cancer risk of workers exposed to 20 ppm styrene by means of the rad-equivalence approach
6.3. Do genetic polymorphisms in genes coding for enzymes involved in metabolism and/or DNA repair explain individual differences in genotoxic responses
6.4. Relevance of genotoxicity assays and genotyping in occupational medicine
7. Summary, conclusions and perspectives for the future
8. Publication list
9. Reference list
Oncology
Environmental Science
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