Experimental Evaluation of the Host Immune Response to
Xenogenic Bio-Derived Collagen Grafts in Rodent Models
Acta Biomedica Lovaniensia, No. 366

By Fang Zheng
September 2006
Leuven University Press
Ph.D. Dissertation
ISBN: 9058675459
131 pages, Illustrated, 6 1/8 x 9 3/8"
$89.50 Paper Original

Chapter 1. Introduction

1.1. Pelvic organ prolapse
1.2. Implants in pelvic floor surgery
1.3. Synthetic implants
1.4. Xenogenic biological grafts
1.5. Inflammatory response to exogenous implants
1.6. Immunogenecity of xenogenic acellular implants
1.7. Aims of the study

Chapter 2. Host response after reconstruction of abdominal wall defects with porcine dermal collagen in a rat model

2.1. Introdcution
2.2. Materila and methods
2.3. Results
2.4. Discussion

Chapter 3. Improved surgical outcome by modification of porcine dermal collagen implant in abdominal wall reconstruction in rats

3.1. Introduction
3.2. Material and methods
3.3. Results
3.4. Discussion

Chapter 4. Characterization of immune response after xenogeneic acellular dermal collagen graft in mice model

4.1. Introduction
4.2. Methods
4.3. Results
4.4. Discussion

Chapter 5. Cytokine production following experimental implantation of xenogenic dermal collagen grafts in mice 5.1. Introduction

5.2. Material and methods
5.3. Results
5.4. Discussion

Chapter 6. The biology behind fascial defects and the use of implants in pelvic organ prolapse repair

Chapter 7. General discussion

7.1. Animal models performed in our studies
7.2. Local inflammatory response to xenogenic acellular implants
7.3. Tensile strength of the xenogenic acellular implants
7.4. Improved surgical outcome by modification of porcine dermal graft
7.5. Participation of different cell populations in pro-inflammatory responses
7.6. Cytokine production in response to xenogenic acellular implants
7.7. Overall conclusions

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