Genetic Analysis of Herpesvirus Entry
Receptors & Host Susceptibility to
Herpes Simplex Virus Infection

By Frank Struyf
September 2004
Leuven University Press
ISBN: 9058674010
125 pages, Illustrated, 6 " x 9 "
$77.50 Paper Original

This is a Ph.D. dissertation. Herpes simplex virus (HSV) is a ubiquitous human pathogen that belongs to the Herpesviridae. The Herpesviridae family of viruses is divided into subfamilies (alpha-, beta- and gammaherpesviruses) based on biologic properties of the agents. Alphaherpesviruses are fast-growing, cytolytic viruses that tend to establish latent infections in neurons; herpes simplex virus (genus Simplexvirus) and varicellazoster virus (genus Varicellovirus) are members of this subfamily.

There are two types of HSV, named HSV-1 and HSV-2 or human herpesvirus types 1 and 2, with approximately 50% DNA sequence similarity between the types. Structurally, herpes simplex viruses contain a double-stranded DNA genome of approximately 150 kilobases, surrounded by an icosapentahedral capsid of about 100 to 110 nanometers in diameter.

Tightly adherent to the capsid is the tegument, which contains viral proteins. A lipid bilayer envelope derived from host cell membranes surrounds the capsid and tegument and contains glycoproteins. These glycoproteins confer distinctive properties to each member of the Herpesvirus family, are necessary for entry into the host cell and provide unique antigens to which the host is capable of responding.

Contents include: Introduction, Mutations in the N-terminal domains of nectin-1 and nectin-2 reveal differences in requirements for entry of various alphaherpesviruses and for nectin-nectin interactions, A mutant form of nectin-1 lacking the second immunoglobulin-like domain inhibits herpes simplex virus entry mediated by nectin-1 and HVEM, Search for polymorphisms in the genes for herpes simplex virus entry mediators HVEM, nectin-1 and nectin-2 in immune seronegative individuals, Discussion.

Acta Biomedica Lovaniensia No. 323

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