Measurement of CYP 3A4 & P-GP Activity
in Vivo using Dynamic Breath & Urine Analysis
Impact on Drug Assimilation in Renal Transplant Recipients

By Wim Lemahieu
March 2005
Leuven University Press
ISBN: 9058674509
183 pages, Illustrated, 6 " x 9 "
$110.00 Paper Original


This is a Ph.D. dissertation. Contents include: General introduction, Measurement of intestinal CYP3A4 and P-Glycoprotein activity by a combined oral and intravenous 14C-Erythromycin breath and urine test, Alterations of CYP3A4 and P-Glycoprotein activity in vivo with time in renal graft recipients, CYP3A4 and P-Glycoprotein activity in healthy controls and transplant patients on cyclosporine vs. Tacrolimus vs. Sirolimus, Impact of gastric acid suppressants on cytochrome P450 3A4 and P-Glycoprotein: consequences for FK506 assimilation, Diarrhoea after transplantation: impact on cytochrome P4503A4/P-Glycoprotein and assimilation of calcineurin inhibitors, Discussion.



Pharmacology
Acta Biomedica Lovaniensia, No. 334

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