Mechanisms of Excitation Contraction
Coupling in Myocytes From Normal
& Chronically Ischemic Pig Myocardium

By Virginie Bito
September 2004
Leuven University Press
ISBN: 905867391X
116 pages, Illustrated, 6 " x 9 "
$75.00 Paper Original

This is a Ph.D. dissertation. Contents include: Introduction, The concept of hibernation and the clinical hallmarks of hibernating myocardium, Mechanisms underlying the contractile dysfunction of hibernating myocardium, Pathophysiology of stunning and the relation to hibernation, Excitation-contraction coupling in cardiac myocytes, Aim, Methods, Pig model of chronic hibernation, Isolation of pig myocytes, Measurement of cell shortening, Measurement of membrane currents, Measurement of [Ca2+], Quantification of t-tubules, Cell volume measurements, Protein expression analysis, Cell culture, Solutions, Statistical analysis, Results, Mechanisms of Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytes, Role of the t-tubules in the spatial and temporal synchrony of sarcoplasmic reticulum Ca2+ release in pig ventricular myocytes, Cellular mechanisms of contractile dysfunction in hibernating myocardium, General discussion, Summary.

Acta Biomedica Lovaniensia No. 317

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