Molecular Modes of Action of
1a,25-Dihydroxyvitamin D3 & Analogs

By Guy Eelen
August 2005
Leuven University Press
ISBN: 9058674754
189 pages, Illustrated, 6 " x 9 "
$99.50 Paper Original


This is a Ph.D. dissertation. Vitamin D was originally identified in the early 1920s as a factor in cod-liver oil that cured rickets, a skeletal disease characterized by undermineralized bones. The German chemist Adolf Windaus described the structure of vitamin D and received the Nobel Prize for chemistry for his work in 1928. Vitamin D is a fat-soluble component that can be derived from either vegetable or animal sources. Fatty fish and fortified dairy products represent important dietary sources of vitamin D.

Contents include: Introduction, Aims of the Study, Materials and Methods, Molecular Mechanisms of the Antiproliferative Action of 1,25-(OH)2D3, Superagonistic 14-EPI-Analogs of 1,25-(OH)2D3 and Enhanced Coactivator Recruitment, General Discussion and Perspectives, Summary.

Biochemistry
Acta Biomedica Lovaniensia, No. 345

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