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Modulation of Nitric Oxide /
Cyclic GMP Signal Transduction in the Injured Vascular Wall

By Peter Sinnaeve
October 2001
Leuven University Press
ISBN: 9058671437
111 pages
$62.50 paper original

Contents include: General introduction. The Nitric Oxide / cyclic GMP pathway. Arterial injury and restenosis. Gene therapy in restenosis. Central hypotheses. Soluble guanylate cyclase gene function in vascular injury. cGMP-dependent protein kinase gene function in vascular injury. Expression of downstream components of the NO/cGMP transduction system after vascular injury. Overexpression of a mutant cGMP-independent protein kinase in in-stent neointima in porcine coronary arteries. Limitations of the study and future perspectives.

Acta Biomedica Lovaniensia, No. 239