Application of Nanotechnology-Based MRI &
Gene Delivery in Treatment of Sensorineural Hearing Loss




By Weikai Zhang
November 2011
Tampere University Press
Distributed by Coronet Books Inc.

ISBN: 9789514485848
146 pages

$87.50 Paper original


The results reported here demonstrate that contrast agent MRI can evaluate inner ear biological barrier function. The novel POA@SPIONs are a promising T2 negative contrast agent, which may be further surface-modified by either peptides or antibodies to increase their use as a diagnostic agent and as traceable therapeutic nanoparticles in SNHL molecular imaging. The nuclear localization of the Math1 protein is important for their function. Neuron-like MSC differentiation mediated by Math1 provides information for future studies of the spiral ganglion neuron-orientated stem cell differentiation.

The nuclear entry and efficient endosomal escape of HPNPs result in high gene transfection efficiency. TrkB ligand-functionalized liposome nanoparticles can potentially be used for the targeted delivery of genes or drugs to spiral ganglion cells. Transfection efficacy and targetability may be improved by using multifunctional nanoparticles, functionalized with peptides or antibodies. Nanoparticle-mediated biological treatment of SNHL is a very promising strategy.

 

Acta Universitatis Tamperensis; 1661

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