Cardiac Contractility & Ca2+ Handling
in Mouse Models of Type II Diabetes
Acta Biomedical Lovaniensia No. 378

By An van den Bergh
December 2006
Leuven University Press
Distributed By Coronet Books
ISBN: 9789058675811
143 pages, Illustrated, 6 1/4 x 9 1/2"
$89.50 Paper Original

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Dankwoord
Abbreviations

1. Introduction

1.1. Clinical relevance
1.2. Ventricular function
1.3. Measuring heart function in mice
1.4. Mouse models

2. Aims

2.1. General aim
2.2. Specific aims

3. General materials and methods

3.1. Mouse models
3.2. Metabolic analysis
3.3. In vivo assessment of pressure-volume loops
3.4. Morphometric analysis
3.5. Immunoblotting
3.6. Oxalate-supported Ca2+ uptake
3.7. Intervention: weight reduction by food restriction
3.8. Spontaneous activity
3.9. Forced activity
3.10. Statistical analysis

4. In vivo cardiac phenotype of the leptin-receptor deficient mouse model of type II diabetes and obesity (DB/DB)69

4.1. Results
4.2. Discussion
4.3. Conclusion

5. In vivo cardiac phenotype of a mouse model of the metabolic syndrome (LDLR-/-; OB/OB)

5.1. Results
5.2. Discussion
5.3. Conclusion

6. In vitro expression and activity of the sarco-endoplasmic reticulum Ca2+ atpase (SERCA2A)in myocardial cells of mouse models of type II DM (OB/OB) and the metabolic syndrome (DKO)

6.1. Results
6.2. Discussion
6.3. Conclusion

7. Effect of weight reduction by fod restriction on hemodynamic variables, exercise tolerance and SR Ca2+ reuptake in mouse models of type II DM and the metabolic syndrome

7.1. Results
7.2. Discussion
7.3. Conclusion

8. General discussion and future perspectives

8.1. The advantage of comprehensive measurements to assess contractility
8.2. Comparison of cardiac performance between a mouse model of type II Dm and a mouse model of the metabolic syndrome

Summary
Samenvatting
Curriculum vitae
Reference list

Medical Science

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