Effects of IL-6 & IL-8 on Respiratory & Peripheral Skeletal Muscle Function
Consequences for Systemic Inflammation in COPD
Acta Biomedica Lovaniensia 375

By Sofie Janssen
December 2006
Institute of Leuven University Press
Distributed by
ISBN: 9058675726
124 pages, 6 x 9½"
$89.50 Paper Original

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Dankwoord
List of abbreviations

Chapter 1: Introduction
1.1. Characterization of COPD
1.2. Inflammation and skeletal muscle function in COPD
1.3. Systemic inflammation and other diseases

Chapter 2: Aims of the Study

Chapter 3: Materials and Methods
3.1. Animal experiments
3.2. Patient experiments

Chapter 4: Effects of IL-6 on skeletal and cardiac muscle function
4.1. In vivo experiments
4.2. In virto experiments

Chapter 5: Effects of IL-8 on skeletal muscle function
5.1. Body and tissue weight
5.2. Diaphragm in vitro contractile properties
5.3. Morphometry of diaphragm and gastrocnemius
5.4. Plasma levels
5.5. Lung histology and water content

Chapter 6: Clinical relevance of peri-operative cytokine levels in heart valve surgery
6.1. Clinical variables
6.2. Haemodynamic variables
6.3. Cytokine and troponin-I plasma levels
6.4. Correlates of preoperative cytokine plasma levels
6.5. Correlates of cytokine plasma levels at the end of surgery
6.6. Correlates of cytokine and troponin-I plasma levels 12 hrs after the end of surgery

Chapter 7: General discussion
7.1. Effects of IL-6 on skeletal muscle function
7.2. Effects of IL-8 on skeletal muscle function
7.3. Clinical relevance of peri-operative cytokine levels in heart valve surgery
7.4. Summary and general conclusion

References
Summary
Samenvatting
Curriculum vitae
List of publications

 

Cardiology


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