Nitric Oxide & Cytochrome P450 Signaling in
Experimental Pulmonary Hypertension
Acta Biomedica Lovaniensia 373

By Peter Pokreisz
December 2006
Institute of Leuven University Press
Distributed by
ISBN: 9058675661
118 pages, 6 x 9½"
$75.00 Paper Original

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List of abbreviations
Acknowledgements

1. Introduction
1.1.Definition of classification of pulmonary hypertension
1.2. Pathophysiology of pulmonary hypertension
1.3. Molecular signalling pathways regulating vascular tone and ventricular hypertrophy in pulmonary hypertension
1.4. Treatment options of pulmonary hypertension
1.5. Experimental models of pulmonary hypertension

2. Hypotheses and aims
2.1. Cytochrome P450 enzymes in pulmonary hypertension
2.2. Nitric oxide in right ventricular hypertrophy

3. Materials and methods
3.1. Experimental animals and chemicals
3.2. Invasive hemodynamic measurements
3.3. Cardiovascular morphometric studies and evaluation of cardiac fibrosis
3.4. Analysis of gene and protein expression
3.5. Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling
3.6. Hypoxia-induced right ventricular hypertrophy in mice with cardiomyocyte-specific overexpression of endothelial nitric oxide synthase
3.7. Statistical analyses

4. Results
4.1. Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasosonstriction and pulmonary vascular remodeling
4.2. Hypoxia-induced right ventricular hypertrophy in mice with cardiomyocyte-specific overexpression of endothelial nitric oxide synthase

5. Discussion
5.1. Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling
5.2. Hypoxia-induced right ventricular hypertrophy in mice with cardiomyocyte-specific overexpression of endothelial nitric oxide synthase

6. Limitations
7. Summary and perspectives
8. References
9. Curriculum Vitae

Pulmonary & Thoracic Medicine


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