Photoproduction of Vitamin D3 & Activation into
1α,25-Dihydroxyvitamin D3 in Human Epidermal
Keratinocytes, Dermal Fibroblasts & Other Cells
Acta Biomedica Lovaniensia 371

By Katleen Vantieghem
December 2006
Institute of Leuven University Press
Distributed by Coronet Books Inc.
ISBN: 9058675610
117 pages, 6 x 9½"
$79.50 Paper Original

Chapter 1: Introduction
1.1. The vitamin D system
1.2. Vitamin D actions
1.3. Vitamin D metabolism
1.4. Transport of vitamin D metabolites
1.5. Mechanism of vitamin D action
1.6. Vitamin D and skin

Chapter 2: Aim and scope of the study

Chapter 3: Materials and methods

Chapter 4: UVB-induced production of 1,25-dihydroxyvitamin D3 and vitamin D activity in human keratinocytes pretreated with a sterol delta7-reductase inhibitor
4.1. Introduction
4.2. Results
4.3. Discussion

Chapter 5: UVB-induced 1,25(OH)2D3 production and vitamin D activity in intestinal CaCo-2cells and in THP-1 macrophages pretreated with a sterol delta7-reductase inhibitor
5.1. Introduction
5.2. Results
5.3. Discussion

Chapter 6: Dermal fibroblasts pretreated with a sterol delta7-reductase inhibitor produce 25-hydroxyvitamin D3 upon UVB irradiation
6.1. Introduction
6.2. Results
6.3. Discussion

Chapter 7: Increased cholesterologenesis and reduced NADPH as possible mechanisms for epidermal 7-DHC accumulation
7.1. Introduction
7.2. Results
7.3. Discussion

Chapter 8: General conclusions and future perspectives
8.1. General conclusions
8.2. Future perspectives



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