Regulation of Intracellular
Ca2+-Release Channels By
Ca2+ & Ca2+-Binding Proteins

By Nael Nadif Kasri
December 2004
Leuven University Press
ISBN: 9058674193
117 pages, Illustrated, 6 " x 9 "
$77.50 Paper Original

This is a Ph.D. dissertation. Almost everything we do is controlled by Ca2+, how we move, how our hearts beat and how our brains process information and store memories. Ca2+ is indeed a ubiquitous second messenger involved in a diversity of cellular activities such as muscular contraction, neurotransmitter release, synaptic plasticity, gene transcription, cell proliferation and apoptosis.

The average cytosolic concentration of Ca2+ in resting cells ranges from 50nM to 100nM, reaching values close to 1uM when the cell is stimulated by a variety of physiological stimuli, while in the extracellular milieu this concentration is about 1mM. This large concentration gradient allows intracellular Ca2+ to work as a useful second messenger. Contents include: General Introduction, Objectives, Results, General Discussion, Summary.

Acta Biomedica Lovaniensia, No. 325

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