Regulation of Ca2+ Release from
the Sarcoplasmic Reticulum in the
Normal & Failing Heart

By Gudrun Antoons
October 2003
Leuven University Press
ISBN: 90-5867-312-X
142 pages, Illustrated, 6 1/4" x 9 1/2"
$59.50 Paper Original

This is a Ph.D. dissertation. Cardiac excitation-contraction (EC) coupling is the process from electrical excitation to contraction of the heart. Electrical stimulation of cardiac cells gives rise to an action potential, which triggers a systolic rise of the intracellular Ca2+ concentration, initiating a contraction. Contents include: Introduction, Excitation-contraction coupling in cardiac muscle, Excitation-contraction coupling in the failing heart, Aims, Methods, Animal models, Cell isolation, Experimental setup, Experimental protocols, Protein expression levels, Echocardiographic measurements, Data analysis, Results, Mechanisms underlying the frequency dependence of contraction and [Ca2+]i transients in mouse ventricular myocytes, Ca2+ handling and contractile dysfunction in ventricular myocytes of MLP, Ca2+ handling in the SERCA 2b/b mouse, General discussion, and Summary.

Acta Biomedica Lovaniensia No. 291

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