Role of Nitric Oxide Synthase in the Regulation of Pulmonary Vascular Tone
Acta Biomedica Lovaniensia, No. 363
By Leifu Jiang
September 2006
Leuven University Press
Ph.D. Dissertation
ISBN: 9058675424
101 pages, Illustrated, 6 1/8 x 9 3/8"
$69.50 Paper Original
Chapter 1: General introduction
1.1. The normal pulmonary circulation
1.2. Pulmonary arterial hypertension
1.3. Experimental pulmonary hypertension
1.4. Genetic engineering
Chapter 2: Aim of the study
Chapter 3: Methods
3.1. Adenovirus-mediated gene transfer
3.2. Exhaled NO measurement
3.3. Isolated vessels preparation
3.4. Quantification of right ventricle hypertrophy
3.5. Induction of hypoxic pulmonary hypertension
3.6. Statistical analysis
Chapter 4: Effect of NOS gene overexpression on isolated pulmonary arteries of normoxic rats
4.1. Introduction
4.2. Study design
4.3. Results
4.4. Discussion
4.5. Conclusion
Chapter 5: Effect of eNOS targeted disruption in isolated mouse pulmonary arteries
5.1. Introduction
5.2. Study design
5.3. Results
5.4. Discussion
5.5. Conclusion
Chapter 6: Vascular reactivity of isolated pulmonary arteries of hypoxic rats
6.1. Introduction
6.2. Study design
6.3. Results
6.4. Discussion
6.5. Conclusion
Chapter 7: Effect of eNOS gene overexpression in isolated pulmonary arteries of chronic hypoxic rats
7.1. Introduction
7.2. Study design
7.3. Results
7.4. Discussion
7.5. Conclusion
Chapter 8: General comments
8.1. Summary of results
8.2. Limitations
8.3. Conclusion
References
List of publications
Summary
Samenvatting
Medical Science
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