Structure/Function Analysis of the Amino-
Terminal Domain of the Androgen Receptor
By Leen Callewaert
Leuven University Press
135 pages, Illustrated, 6 ¼" x 9 ½"
$65.00 Paper Original
This is a Ph.D. dissertation. The amino-terminal domain (NTD) of the androgen receptor (AR) is indispensable for AR transactivation and contains a strong activation function 1. Its activity is affected by coregulators that influence a number of functional properties of AR. The NTD of the AR is 529 aa long and is a complex domain with several functions, namely p160 recruitment, interaction with the LBD, and it contains two transactivation functions Tau-1 And Tau-5. The aim of this study was to obtain a more detailed structure-function analysis of the NTD of the AR. Contents include: Introduction, N/C Interaction in AR-mediated Transactivation, Polyglutamine Stretch, SUMOylation of the AR, Activation Function of the hAR, Discussion, Summary and conclusions, Future Prospects.
Acta Biomedica Lovaniensia, No. 308
Return to Coronet Books main page