Structure-Function Relationship
& Modulation of the T-type
Calcium Channel a1G

By Karel Talavera Perez
September 2004
Leuven University Press
ISBN: 9058673820
110 pages, Illustrated, 6 " x 9 "
$59.50 Paper Original


This is a Ph.D. dissertation. Contents include: General introduction, Diversity and structure of voltage dependent Ca2+ Channels, Biophysical properties of T-type Ca2+ Channels, Tissue distribution and physiological roles, Modulation and pharmacological roles, Modulation and pharmacology, Studies on structure-function relationship, Objectives, Results, Aspartate residues of the GLU-GLU-ASP-ASP (EEDD) pore locus control selectivity and permeation of the T-type Ca2+ Channel a1G, Pore structure influences gating properties of the T-type Ca2+ Channel a1G, Extracellular Ca2+ modulates the effects of protons on gating and conduction properties of the T-type Ca2+ Channel a1G, Mechanisms of arachidonic acid modulation of the T-type Ca2+ Channel a1G, Insights in the conduction properties of T-type Ca2+ Channels, The structure of the selectivity filter influences the gating properties of a1G, Modulation of T-type Channel gating by extracellular protons and Ca2+, Modulation of T-type channels by arachidonic acid, summary.

Biochemistry
Acta Biomedica Lovaniensia No. 313

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