Study of the Relation between the Metabolic Syndrome,
Coronary Atherosclerosis & Heart Failure in a Mouse Model
Acta Biomedica Lovaniensia, No. 360

By Wim Verreth
September 2006
Leuven University Press
Ph.D. Dissertation
ISBN: 9058675386
168 pages, Illustrated, 6 1/8 x 9 3/8"
$110.00 Paper Original

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Chapter 1: General introduction

1.1. Cardiovascular diseases
1.2. Metabolic syndrome
1.3. Peroxisome proliferator-activated receptor and metabolic syndrome
1.4. Mouse model for the metabolic syndrome
1.5. Aims

Chapter 2: Weight loss-associated induction of peroxisome proliferator-activated receptor-a and peroxisome proliferator-activated receptor-? correlate with reduced atherosclerosis and improved cardiovascular function in obese insuline-resistant mice

2.1. Abstract
2.2. Introduction
2.3. Methods
2.4. Results
2.5. Discussion
2.6. References

Chapter 3: PPARa,?-agonist improves insulin sensitivity and prevents loss of left ventricular function in obese dyslipidemic mice

3.1. Abstract
3.2. Introduction
3.3. Methods
3.4. Results
3.5. Discussion
3.6. References

Chapter 4: Rosuvastatin increases insulin sensitivity and reduces atherosclerotic plaque volume a,d plaque macrophage and oxidized LDL content in obese dyslipidemic mice in the absence of cholesterol reduction

4.1. Abstract
4.2. Introduction
4.3. Methods
4.4. Results
4.5. Discussion
4.6. References

Chapter 5: Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse model of metabolic syndrome

5.1. Abstract
5.2. Introduction
5.3. Methods
5.4. Results
5.5. Discussion
5.6. References

Chpater 6: Discussion, conclusions and perspectives

6.1. The metabolic syndrome in relation to cardiovascular diseases
6.2. Mouse model for the metabolic syndrome
6.3. Summary of ouor main findings
6.4. Future perspectives

References

Summary

Samenvatting

Curriculum Vitae

Publication list

Cardiology



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